منابع مشابه
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With the sequencing of the human genome it turned out that many of the genetically identified genes have an unknown function and one of the major problems of biology is the “annotation” of the genome. But the reverse problem persists, i.e., that for many functionally well-defined proteins the coding gene has not been identified. This reverse problem is difficult to tackle because the molecular ...
متن کاملCa2+-activated Chloride Channels Go Molecular
With the sequencing of the human genome it turned out that many of the genetically identified genes have an unknown function and one of the major problems of biology is the " annotation " of the genome. But the reverse problem persists, i.e., that for many functionally well-defined proteins the coding gene has not been identified. This reverse problem is difficult to tackle because the molecula...
متن کاملTamoxifen Blocks Chloride Channels
Tamoxifen is an antiestrogen frequently used in the treatment of breast cancer and is currently being assessed as a prophylactic for those at high risk of developing tumors. We have found that tamoxifen and its derivatives are highaffinity blockers of specific chloride channels. This blockade appears to be independent of the interaction of tamoxifen with the estrogen receptor and therefore refl...
متن کاملCalcium-activated chloride channels.
Calcium-activated chloride channels (CaCCs) play important roles in cellular physiology, including epithelial secretion of electrolytes and water, sensory transduction, regulation of neuronal and cardiac excitability, and regulation of vascular tone. This review discusses the physiological roles of these channels, their mechanisms of regulation and activation, and the mechanisms of anion select...
متن کاملClC-2 chloride channels contribute to HTC cell volume homeostasis.
Membrane Cl(-) channels play an important role in cell volume homeostasis and regulation of volume-sensitive cell transport and metabolism. Heterologous expression of ClC-2 channel cDNA leads to the appearance of swelling-activated Cl(-) currents, consistent with a role in cell volume regulation. Since channel properties in heterologous models are potentially modified by cellular background, we...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2001
ISSN: 0022-3751,1469-7793
DOI: 10.1111/j.1469-7793.2001.0581e.x